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Stem Cell Therapy

Osteoarthritis is the leading cause of pain and disability worldwide. It can affect any joint, but knee OA is the most common. OA is a chronic, progressive and debilitating disease that erodes articular cartilage that covers and protects the ends of bones from friction and allows our joints to move smoothly.

Permanent cartilage loss leads to pain, disability, limited mobility, and loss of quality of life. Because cartilage has a limited blood supply it has little capacity to repair or rebuild itself.

Current treatments aim to control the pain and symptoms but provide only modest benefits and do not affect the course of the disease.  There is no drug treatment that can alter the course of OA.

OA is the most common reason for total hip and total knee replacement surgery which has significant risks and requires a lengthy rehabilitation. Other surgical approaches to repair the damaged cartilage include transplantation of cartilage cells, and microfracture. But these techniques are limited to repair of small and some medium cartilage defects.

Stem cell therapy is being used successfully for major bone and joint injuries, osteoarthritis, ligament and tendon injuries, and other orthopedic applications.

Regenerative joint preservation is a vital and viable option to restore function and reduce pain. Cell-based therapies like stem cell therapy can repair and regenerate the structure and function of articular cartilage. Stem cell therapy may be supplemented with Platelet-rich plasma to deliver growth factors to magnify stem cell efficacy for better healing of cartilage.

What are stem cells?

Stem cells are our body’s natural resource for cell and tissue repair and renewal.  As we age, the regenerative capacity of our stem cells declines, and can lead to various age-related diseases and conditions, and poor capacity healing and repair of injuries. Since we live longer and are more active musculoskeletal injury and disease increase. The result is more disability and poorer quality of life.

Stem cell therapy offers the opportunity to repair and heal worn out and damaged tissues naturally, without the need for surgery. Stem cells modulate the immune response to injury, regenerate musculoskeletal tissues and prevent tissue damage. The result is improved mobility, better quality of life and better outcomes.

What are stem cells?

Mesenchymal stem cells (MSCs) have the unique ability to replicate themselves, and develop into bone, cartilage, ligament and tendon cells which the body uses to maintain, repair and rebuild tissue. MSCs can be obtained from bone, tendon, skin, adipose tissue, umbilical cord blood and amniotic fluid.

How do stem cells work?

MSCs work by replacing impaired and failing cells with healthy cells to heal and maintain damaged tissues. They naturally release anti-inflammatory chemicals that decrease inflammation and pain. MSCs create new blood cells to improve healing, especially in tissues with a poor blood supply including cartilage, tendons and ligaments. The result is tissue regeneration, pain relief, and improved function.

The benefits of stem cell therapy

In OA, MSCs differentiate into cartilage and bone, reduce inflammation that causes cartilage degeneration, rejuvenates cartilage and can modify the course of the disease. Stem cell therapy offers the opportunity of regenerative joint preservation with MSCs to improve pain and function, delay progression of OA, and delay or eliminate the need for joint replacement. 

Advantages include accelerated healing and pain relief that can last for years, and in some cases, can permanently eliminate pain and disability. This therapy can reduce the need for extensive physical therapy and rehabilitation, usually necessary after surgery or an injury. Stem cell therapy can help heal damaged cartilage and treat the underlying disease helping patients avoid joint replacement surgery.

Am I a good candidate?

If you suffer with joint, tendon, or ligament pain or joint arthritis, and desire to improve your quality of life, and avoid invasive surgery and potential complications, stem cell therapy may be for you.

Not everyone is a candidate for stem cell therapy. The only way to know if you are a good candidate is to schedule a consultation.

At Physicians Rehabilitation, every patient receives a customized treatment plan based on their needs and is designed to produce superior results. The health-restoring benefits improve quality of life and in some cases, patients can avoid surgical treatment and lengthy recovery. For your convenience, we have offices in Fort Myers, Lady Lake, Naples, Port Charlotte and Sun City Center Florida. Contact us to learn about how stem cell therapy can restore your health and quality of life.


  • Akpancar S, et al. The current perspectives of stem cell therapy in orthopedic surgery. Arch Trauma Res. 2016 Dec;5(4); e37976
  • Dubey NK, et al. Combating Osteoarthritis through Stem Cell Therapies by Rejuvenating Cartilage: A Review. Stem Cells Int. 2018; 2018: 5421019.
  • Freitag J. et al. Mesenchymal stem cell therapy in the treatment of osteoarthritis: reparative pathways, safety and efficacy – a review. BMC Musculoskeletal Disorders. 2016:17:230.
  • McIntyre JA, et al. Intra-articular Mesenchymal Stem Cell Therapy for the Human Joint: A Systematic Review. Am J Sports Med. 2018 Dec;46(14):3550-3563.
  • Vega, A, et al. “Treatment of Knee Osteoarthritis with Allogeneic Bone Marrow Mesenchymal Stem Cells: A randomized Controlled Trial. Transplantation. 2015 Aug; 99(8): 1681-1690.

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